Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae

Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae

Blog Article

The Enterobacteriaceae family are the most common pathogens associated with hospital and community acquired infections worldwide.These bacteria are treated with broad spectrum antibiotics especially 3rd generation cephalosporins.Over the period of time due widespread and rigorous use of these Understanding extreme precipitation scaling with temperature: insights from multi-spatiotemporal analysis in South Korea medications, Enterobacteriaceae has developed antibiotic resistance (AMR).

Among all, the most compelling antibiotic resistance mechanism is production of -lactamases enzymes by this microorganism.Over the course of time -lactamase has evolved more than 1300 distinct enzymes.Amongst these most deleterious is extended spectrum beta lactamases (ESBL).

ESBL producing Enterbacteriacaeae are responsible for a high number of deaths worldwide.These enzymes are considered challenging AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model as they are difficult to be identified in the laboratory wShich cause delay in diagnosis and administration of appropriate antimicrobial therapy.The coexistence of ESBL with other antibiotic resistance gene is another therapeutic challenge rendering empirical antibiotic treatment ineffective.